Odborné zdroje

1. Rannou F et al. Efficacy and safety of topical NSAIDs in the management of osteoarthritis: Evidence from real-life setting trials and surveys. Seminars inArthritisandRheumatism45(2016)S18–S21.
2. Cordero JA, Alarcon L, Escribano E et al. A comparative study of the transdermal penetration of a series of nonsteroidal antiinflammatory drugs. J Pharm Sci. 1997; 86: 503–508
3. Sengupta S et al. Analgesic efficacy and pharmacokinetics of topical nimesulide gel in healthy human volunteers: double-blind comparison with piroxicam, diclofenac and placebo. Eur J Clin Pharmacol. 1998 Sep;54(7):541-7.
4. BruyereO,CooperC,PelletierJP,BrancoJ,BrandiML,GuilleminF,etal.An algorithm recommendation for the management of knee osteoarthritis in Europe and internationally: a report from a task force of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO). Semin ArthritisRheum2014;44:253–63.
5. Doporučení České revmatologické společnosti pro léčbu osteoartrózy kolenních, kyčelních a ručních kloubů. Čes. Revmatol., 20, 2012, No. 3, p.
6. Analgesics for Osteoarthritis: An Update of the 2006 Comparative Effectiveness Review. AHRQ Publication No. 11(12)-EHC076-EF October 2011.
7. Hochberg MC et al. American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee. Arthritis Care & Research. Vol. 64, No. 4, April 2012, pp 465-474.
8. Ondarza A et al. Placebo Effect of Transdermal NSAIDS. Applied Clinical Trials-06-01-2011, Volume 20, Issue 6.
9. Baer PA et al. Treatment of osteoarthritis of the knee with a topical diclofenac solution: a randomised controlled, 6-week trial. BMC Musculoskelet Disord. 2005 Aug 8;6:44.
10. Bookman AAM et al. Effect of a topical diclofenac solution for relieving symptoms of primary osteoarthritis of the knee: a randomized controlled trial. CMAJ. 2004 Aug 17;171(4):333-8.
11. Borisenko OV, Belen´kiï. [Impact of combined therapy using glucosamine sulfate and anti-inflammatory agent on pain severity in patients with osteoarthritis: prospective, non-controlled postmarketing study]. Klin Med (Mosk). 2013;91(5):65-71.
12. Underwood M et al. Advice to use topical or oral ibuprofen for chronic knee pain in older people: randomised controlled trial and patient preference study. BMJ 2008; 336.
13. Kloppenburg M et al. 2018 update of the EULAR recommendations for the management of hand osteoarthritis. Ann Rheum Dis 2019;78:16–24.
14. Zacher J et al. Topisches Diclofenac Emulgel versus orales Ibuprofen in der Therapie der aktivierten Arthrose der Fingergelenke (Heberden- und/oder Bouchard-Arthrose) – Doppelblinde, kontrollierte, randomisierte Studie. Aktuelle Rheumatologie 26(1):7-14.
15. Zeng Ch et al. Relative efficacy and safety of topical non-steroidal anti-inflammatory drugs for osteoarthritis: a systematic review and network meta-analysis of randomised controlled trials and observational studies. Br J Sports Med 2018;52:642–650.
16. Barkin RL. Topical nonsteroidal anti-inflammatory drugs: the importance of drug, delivery, and therapeutic outcome. Am J Ther 2015;22:388-407.
17. Conaghan PG et al. A multicentre, randomized, placebo- and active-controlled trial comparing the efficacy and safety of topical ketoprofen in Transfersome gel (IDEA-033) with ketoprofen-free vehicle (TDT 064) and oral celecoxib for knee pain associated with osteoarthritis. Rheumatology, Volume 52, Issue 7, July 2013, Pages 1303–1312.
18. Folzer E, Gonzalez D, Singh R, et al. Comparison of skin permeability for three diclofenac topical formulations: an in vitro study. Pharmazie 2014;69:27-31.
19. Zacher J, Altman R, Bellamy N, et al. Topical diclofenac and its role in pain and inflammation: an evidence-based review. Curr Med Res Opin 2008;24:925-50.
20. Biswal S, Medhi B, Panhi P, et al. Long-term efficacy of nonsteroidal antiinflammatory drugs in knee OA: metaanalysis of randomized placebo controlled trials. J Rheumatol 2006;33:1841-1844.
21. Trnavský et al. Efficacy and safety of 5% ibuprofen cream treatment in knee osteoarthritis. Results of a randomized, double-blind, placebo-controlled study. J Rheumatol. 2004 Mar;31(3):565-72.

Odborné odkazy Traumaplant

Kučera M. et al. Efficacy and safety of topically applied Symphytum herb extract cream in the treatment of ankle distortion: Results of a randomized controlled clinical double-blind study. Wiener Medizinische Wochenschrift volume 154, pages498–507(2004).

Koll R. et al. Efficacy and tolerance of a comfrey root extract (Extr. Rad. Symphyti) in the treatment of ankle distorsions: results of a multicenter, randomized, placebo-controlled, double-blind study. Phytomedicine. 2004 Sep;11(6):470-7.

Predel HG et al. Efficacy of a comfrey root extract ointment in comparison to a diclofenac gel in the treatment of ankle distortions: results of an observer-blind, randomized, multicenter study. Phytomedicine. 2005 Nov;12(10):707-14.